Chromosome stability, DNA recombination and the BR...[Curr Opin Cell Biol. 2001]

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1: Curr Opin Cell Biol. 2001 Jun;13(3):338-43. Links

Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.

Venkitaraman AR.

University of Cambridge, CRC Department of Oncology, The Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK. arv22@cam.ac.uk

The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.

PMID: 11343905 [PubMed - indexed for MEDLINE]

The BRCA2 gene product functionally interacts with p53 and RAD51. [Proc Natl Acad Sci U S A. 1998]
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. [Mol Cell. 2001]
BRCA2 is required for homology-directed repair of chromosomal breaks. [Mol Cell. 2001]
The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination? [Philos Trans R Soc Lond B Biol Sci. 2000]
BRCA2 and homologous recombination. [Breast Cancer Res. 2001]
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Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.

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