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    Curr Opin Cell Biol. 2001 Jun;13(3):338-43.

    Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.

    Venkitaraman AR.

    University of Cambridge, CRC Department of Oncology, The Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK. arv22@cam.ac.uk

    The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.

    PMID: 11343905 [PubMed - indexed for MEDLINE]

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