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Curr Opin Cell Biol. 2001 Jun;13(3):290-301.

Spliceosomal UsnRNP biogenesis, structure and function.

Author information

  • 1Max Planck Institute of Biophysical Chemistry, Department of Cellular Biochemistry, Am Fassberg 11, 37077 Göttingen, Germany. cwill1@gwdg.de

Abstract

Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.

PMID:
11343899
[PubMed - indexed for MEDLINE]
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