Derivation of dendritic cells from myeloid and lymphoid precursors

Int Rev Immunol. 2001 Feb;20(1):117-35. doi: 10.3109/08830180109056726.

Abstract

The antigen presenting dendritic cells (DC) found in mouse and human lymphoid tissues are heterogeneous. Several subsets of mature DC have been described and these may correspond to distinct lineages. In this review, we present evidence obtained from a series of studies on the lineage origin of DC. This evidence points to the existence of at least three pathways for DC development, namely one from myeloid progenitors, a second from lymphoid progenitors and the third for Langerhans cells from precursors whose relationship to myeloid or lymphoid cell types is not yet clearly defined.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation
  • Blood Cells / cytology
  • Bone Marrow Cells / cytology
  • Cell Differentiation
  • Cell Lineage
  • Cells, Cultured
  • Colony-Forming Units Assay
  • Dendritic Cells / classification
  • Dendritic Cells / cytology*
  • Dendritic Cells / immunology
  • Gene Expression Regulation, Developmental
  • Granulocyte-Macrophage Colony-Stimulating Factor / physiology
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / drug effects
  • Humans
  • Lymphocytes / cytology*
  • Mice
  • Mice, Knockout
  • Monocytes / cytology
  • Myeloid Cells / cytology*
  • Organ Specificity
  • Phagocytes / cytology
  • Stem Cells / cytology
  • Thymus Gland / cytology
  • Transcription Factors / deficiency
  • Transcription Factors / genetics
  • Transcription Factors / physiology
  • Tumor Necrosis Factor-alpha / physiology

Substances

  • Transcription Factors
  • Tumor Necrosis Factor-alpha
  • Granulocyte-Macrophage Colony-Stimulating Factor