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Expert Opin Pharmacother. 2001 May;2(5):799-811.

The pathophysiological role of prostaglandins in penile erection.

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  • 1Pyrah Department of Urology, St James's University Hospital, Leeds, UK.


Penile erection is a complex haemodynamic event and relaxation of the vascular smooth muscle of the penis is fundamental to this process. This is primarily mediated by nitric oxide (NO) produced from non-adrenergic non-cholinergic (NANC) nerves and the endothelium surrounding the corporal sinusoids. However, corporal tissue has been shown to produce a number of other vasoactive factors, including prostaglandins (PGs), which appear to not only have diverse physiological effects, but are also able to modulate the effects of other neurotransmitters, including NO.

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