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1: Nat Rev Mol Cell Biol. 2001 May;2(5):392-6.Click here to read Links

Cell control by membrane-cytoskeleton adhesion.

Sheetz MP.

Department of Biological Sciences, PO Box 2408, Columbia University, Sherman Fairchild Center, 1212 Amsterdam Avenue, New York, NY 10027, USA. ms2001@columbia.edu

The rates of mechanochemical processes, such as endocytosis, membrane extension and membrane resealing after cell wounding, are known to be controlled biochemically, through interaction with regulatory proteins. Here, I propose that these rates are also controlled physically, through an apparently continuous adhesion between plasma membrane lipids and cytoskeletal proteins.

PMID: 11331914 [PubMed - indexed for MEDLINE]