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Molecular targets for breast cancer therapy and prevention.
Max-Planck-Institut of Biochemistry, Department of Molecular Biology Martinsried, Germany.
The recent completion of the human genome sequence has raised great hopes for the discovery of new breast cancer therapies based on newly-discovered genes linked to breast cancer development and progression. Here we describe breast cancer therapies that have emerged from gene-based scientific efforts over the past 20 years and that are now approved for clinical testing or treatment.
PMID: 11329054 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Overexpression of Eag1 potassium channels in clinical tumours.
Hemmerlein B, Weseloh RM, Mello de Queiroz F, Knötgen H, Sánchez A, Rubio ME, Martin S, Schliephacke T, Jenke M, Heinz-Joachim-Radzun, et al.
Mol Cancer. 2006 Oct 5; 5:41. Epub 2006 Oct 5.
[Mol Cancer. 2006]
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Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.
Sukocheva O, Wadham C, Holmes A, Albanese N, Verrier E, Feng F, Bernal A, Derian CK, Ullrich A, Vadas MA, et al.
J Cell Biol. 2006 Apr 24; 173(2):301-10.
[J Cell Biol. 2006]
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Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins.
Egland KA, Vincent JJ, Strausberg R, Lee B, Pastan I.
Proc Natl Acad Sci U S A. 2003 Feb 4; 100(3):1099-104. Epub 2003 Jan 21.
[Proc Natl Acad Sci U S A. 2003]
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