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J Paediatr Child Health. 2001 Apr;37(2):146-51.

Leucocyte populations in respiratory syncytial virus-induced bronchiolitis.

Author information

  • 1Department of Paediatrics, Flinders Medical Center, Flinders University, Adelaide, South Australia, Australia.

Abstract

OBJECTIVES:

To enumerate the cellular composition of the airways in infants with acute bronchiolitis.

METHODOLOGY:

Cells were obtained by airway lavage from the upper and lower airway and the peripheral blood of infants with respiratory syncytial virus (RSV)+ bronchiolitis, RSV- bronchiolitis and age-matched controls.

RESULTS:

Neutrophils are the predominant cells present in the upper and lower airway. Neutrophils are present at a higher number/unit volume in the airway than in the peripheral blood.

CONCLUSIONS:

Neutrophils, being the dominant cellular infiltrate into the airway, are likely to contribute to the pathophysiology of bronchiolitis. Therapies targeted at limiting neutrophil influx or neutrophil-mediated damage in the airway may have a therapeutic role.

PMID:
11328469
[PubMed - indexed for MEDLINE]
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