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Bioorg Med Chem Lett. 2001 Apr 23;11(8):977-80.

Novel inhibitors of Leishmanial dihydrofolate reductase.

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  • 1Welsh School of Pharmacy, Cardiff University, UK.


The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays.

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