High cardiac angiotensin-II-forming activity in infarcted and non-infarcted human myocardium

Cardiology. 2000;94(4):247-53. doi: 10.1159/000047325.

Abstract

The aims of this study were to compare human cardiac angiotensin-II-forming activity (AIIFA) between the intact area of control autopsy hearts without cardiac disease (n = 10) and the infarcted or non-infarcted area of autopsy hearts with myocardial infarction (MI, n = 7) and to determine responsible angiotensin-II-forming enzymes. Cardiac total and chymase-dependent AIIFAs were significantly higher in the infarcted and non-infarcted myocardium than those in non-MI heart, while angiotensin-converting enzyme-dependent AIIFA increased only in the infarcted myocardium. The density of chymase antibody-positive mast cells in the non-infarcted area of MI heart correlated positively with total or chymase-dependent AIIFA. Augmented AIIFA was also detected in the left atrium of post-MI hearts. Our results indicated that cardiac angiotensin II formation could be activated in the infarcted as well as in non-infarcted myocardium of the post-MI human heart.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Angiotensin II / analysis
  • Autopsy
  • Chymases
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / enzymology
  • Myocardial Infarction / metabolism*
  • Myocardium / enzymology
  • Myocardium / pathology*
  • Peptidyl-Dipeptidase A / analysis*
  • Renin / metabolism*
  • Serine Endopeptidases / metabolism

Substances

  • Angiotensin II
  • Peptidyl-Dipeptidase A
  • Serine Endopeptidases
  • Chymases
  • Renin