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Cancer Res. 2001 May 1;61(9):3806-9.

Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer.

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  • 1Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong. xyguan@hkucc.hku.hk

Abstract

Amplification of 3q25-q26 was one of the most frequent chromosomal alterations in human ovarian carcinoma. A chromosome microdissection-hybrid selection method was applied to isolate transcribed sequences from a primary ovarian cancer containing high-copy-number amplification of 3q26 using 3q26 band-specific DNAs generated by chromosome microdissection. Using this method, we have isolated a novel candidate oncogene eIF-5A2 (eukaryotic initiation factor 5A2). eIF-5A2 shares 82% identity of amino acid sequence with eIF-5A including the minimum domain needed for eIF-5A maturation by hypusine modification at lysine-50 residue. Amplification and overexpression of eIF-5A2 was frequently detected in primary ovarian cancers and ovarian cancer cell lines. The proliferation-related function of eIF-5A supports that eIF-5A2 is a candidate oncogene related to the development of ovarian cancer.

PMID:
11325856
[PubMed - indexed for MEDLINE]
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