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Acta Pharmacol Sin. 2000 May;21(5):450-4.

Anti-hepatoma activity of taxol in vitro.

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  • 1Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.

Abstract

AIM:

To investigate the in vitro anti-hepatoma activity of taxol against SMMC-7721 human hepatoma cells.

METHODS:

The hepatoma cell growth was measured by MTT-microculture tetrazolium assay. Cell-cycle kinetics and apoptosis were analyzed by flow cytometry and microscopic examination.

RESULTS:

Taxol inhibited the hepatoma cell growth in concentration- and time-dependent manners with IC50 of 18.96 nmol.L-1. Marked cell accumulation in G2/M phase and multinucleated cells were also observed after treatment with taxol 10 nmol.L-1. In addition, taxol at 10 nmol.L-1 could induce the apoptosis of hepatoma cells.

CONCLUSION:

Taxol suppresses the growth of SMMC-7721 human hepatoma cells in vitro by causing cell-cycle arrest, aberrant mitosis, and apoptosis of the human hepatoma cells.

PMID:
11324445
[PubMed - indexed for MEDLINE]
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