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    FEBS Lett. 2001 Apr 20;495(1-2):120-5.

    The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.

    Vanhalst K, Kools P, Vanden Eynde E, van Roy F.

    Source

    Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University, Ledeganckstraat 35, B-9000, Ghent, Belgium.

    Abstract

    Extensive cDNA analysis demonstrated that all human and mouse protocadherin-beta genes are one-exon genes. The protein sequences of these genes are highly conserved, especially the three most membrane-proximal extracellular domains. Phylogenetic analysis suggested that this unique gene family evolved by duplication of one single protocadherin-beta gene to 15 copies. The final difference in the number of protocadherin-beta genes in man (#19) and mouse (#22) is probably caused by duplications later in evolution. The complex relationship between human and mouse genes and the lack of pseudogenes in the mouse protocadherin-beta gene cluster suggest a species-specific evolutionary pressure for maintenance of numerous protocadherin-beta genes.

    PMID:
    11322959
    [PubMed - indexed for MEDLINE]

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