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FEBS Lett. 2001 Apr 20;495(1-2):12-5.

Mitochondrial permeability transition and oxidative stress.

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  • 1Departamento de Bioquímica, Instituto de Quimica, Universidade de São Paulo, São Paulo, SP, Brazil.


Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.

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