Continuous facial myokimia (CFM) are characterized by a contracted facial appearance and vermicular movements that spread across a hemiface. Pontine lesions are their most frequent cause. Although their occurrence during the course of multiple sclerosis is not uncommun, CFM are rarely the first sign of the disease. We report two cases of CMF as first manifestation of multiple sclerosis. Multiple sclerosis is the first diagnosis to suspect in young people with CFM.