Display Settings:

Format

Send to:

Choose Destination
Cytokine Growth Factor Rev. 2001 Mar;12(1):33-40.

Interleukin-6 and prostate cancer progression.

Author information

  • 1Unit for Laboratory Animal Medicine, Institute of Gerontology and Connective Tissue Oncology Program, Room 5304 CCGCB, 1500 E. Medical Center Drive, University of Michigan, Ann Arbor, MI 48109-0940, USA.

Abstract

Prostate cancer, while initially dependent on androgens for proliferation, progresses to an androgen-independent state. Evidence has been accumulating that interleukin-6 (IL-6) may contribute to prostate cancer progression. Serum levels of IL-6 correlate with prostate tumor burden and patient morbidity. The prostate tissue itself appears to be a source of IL-6 and its receptor. Furthermore, experimental data suggest that IL-6 is an autocrine and paracrine growth factor for androgen-independent prostate cancer cell lines. For example, inhibition of IL-6, with anti-IL-6 antibody, sensitizes androgen-independent prostate cancer cells to chemotherapeutic agents in vitro. Finally, IL-6 activates a variety of signal transduction cascades, some which stimulate androgen receptor activity, in prostate cancer cells. These data suggest that targeting IL-6 may have multiple benefits in prostate cancer patients.

PMID:
11312117
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk