Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Stat Methods Med Res. 2000 Dec;9(6):543-62.

Statistical designs for familial aggregation.

Author information

  • 1Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA. kyliang@jhsph.edu

Abstract

In the past two decades, it has become increasingly clear that genetic factors contribute to the aetiology of many common diseases including cancers, coronary disease, allergy and psychiatric disorders. While one goal of genetic epidemiological studies is to locate susceptibility genes for these complex diseases, it is important that strong evidence of familial aggregation be established at an early stage of research. In this paper, we discuss several study designs useful to address some issues such as (1) detecting familial aggregation, (2) testing for gene-environment interaction, (3) identifying homogeneous subgroups and (4) measuring magnitude and patterns of familial correlations. These designs include the conventional case-control design and the family case-control design. For each of these two study designs, we discuss analytical strategies as well as their strengths and weaknesses. Throughout, several examples from real studies are used for illustrative purposes.

PMID:
11308070
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk