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Exp Cell Res. 2001 May 1;265(2):195-202.

Histone acetylation and chromatin remodeling.

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  • 1Institut für Physiologische Chemie, Universität München, Schillerstrasse 44, D-80336 Munich, Germany.

Abstract

Chromatin represents a repressive barrier to the process of transcription. This molecular obstacle is a highly dynamic structure, able to compact the DNA of the entire genome into the confines of a nucleus, and yet it allows access to the genetic information held within. The acetylation of histones has emerged as a regulatory mechanism capable of modulating the properties of chromatin and thus the competence of the DNA template for transcriptional activation. The role of acetylation in chromatin remodeling is therefore of paramount importance to our understanding of gene regulation in vivo.

Copyright 2001 Academic Press.

PMID:
11302684
[PubMed - indexed for MEDLINE]
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