Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2001 Apr;11(2):240-9.

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders.

Author information

  • 1Mood and Anxiety Disorders Program, National Institutes of Mental Health, 1 Center Drive, Room B3-07 MSC 0135, Bethesda, MD 20892-0135, USA.


Neuroimaging technology has provided unprecedented opportunities for elucidating the anatomical correlates of major depression. The knowledge gained from imaging research and from the postmortem studies that have been guided by imaging data is catalyzing a paradigm shift in which primary mood disorders are conceptualized as illnesses that involve abnormalities of brain structure, as well as of brain function. These data suggest specific hypotheses regarding the neural mechanisms underlying pathological emotional processing in mood disorders. They particularly support a role for dysfunction within the prefrontal cortical and striatal systems that normally modulate limbic and brainstem structures involved in mediating emotional behavior in the pathogenesis of depressive symptoms.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk