Arch Pathol Lab Med. 2001 May;125(5):669-72.

Lymphoepithelioma-like carcinoma of the breast with associated sclerosing lymphocytic lobulitis.

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Division of Anatomical Pathology, School of Pathology and Laboratory Medicine, University of Natal, Durban, South Africa.

Abstract

The purpose of this article is to highlight an unusual form of breast carcinoma and discuss its differential diagnosis. A 50-year-old woman underwent wide local excision of a breast lump. Microscopic examination revealed features of a lymphoepithelioma-like carcinoma. Individual tumor cells were present within an abundant lymphoid stroma. Immunohistochemistry revealed the epithelial nature of the cells and excluded a diagnosis of lymphoma. In addition, surrounding nontumorous breast tissue displayed the histologic features of sclerosing lymphocytic lobulitis or lymphocytic mastopathy. This is the second report of a lymphoepithelioma-like carcinoma of the breast, but to the best of our knowledge, it is the first description of coexistent sclerosing lymphocytic lobulitis.

PMID:: 11300942; [PubMed - indexed for MEDLINE]

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