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    Trends Biochem Sci. 2001 Apr;26(4):213-4.

    Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain.

    Fagan R, Swindells M, Overington J, Weir M.

    Inpharmatica, 60 Charlotte St, W1T 2NU, London, UK. r.fagan@inpharmatica.co.uk

    Nicastrin, a protein implicated in Alzheimer's disease, has a domain that is found in the aminopeptidase/transferrin receptor superfamily. In nicastrin, this domain might possess catalytic activity (as observed with aminopeptidases) or it could serve merely as a binding domain (with analogy to the transferrin receptors) for the beta-amyloid precursor protein.

    PMID: 11295540 [PubMed - indexed for MEDLINE]

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