Endocr Rev. 2001 Apr;22(2):153-83.

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH.

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Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

PMID:: 11294822; [PubMed - indexed for MEDLINE]

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Publication Types, MeSH Terms, Substances, Grant Support

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MeSH Terms

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Mitogen-Activated Protein Kinases

Grant Support

T32 GM-07062/GM/NIGMS NIH HHS/United States

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