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    Genes Immun. 2001 Feb;2(1):52-5.

    Cloning and characterization of TNKL, a member of tankyrase gene family.

    Kuimov AN, Kuprash DV, Petrov VN, Vdovichenko KK, Scanlan MJ, Jongeneel CV, Lagarkova MA, Nedospasov SA.

    Source

    Laboratory of Molecular Immunology, A.N. Belozersky Institute of Physico-Chemical Biology and Center for Molecular Medicine, Moscow State University, Russia.

    Abstract

    By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.

    PMID:
    11294570
    [PubMed - indexed for MEDLINE]
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