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Am J Clin Pathol. 2001 Apr;115(4):567-70.

Platelet satellitism as presenting finding in mantle cell lymphoma. A case report.

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  • 1Department of Pathology, Medical College of Virginia Hospitals of Virginia Commonwealth University, Richmond, USA.

Abstract

Platelet satellitism surrounding polymorphonuclear neutrophils has been observed almost exclusively in EDTA-treated blood at room temperature. The mechanism underlying this phenomenon is not understood fully. We report a case of platelet rosetting around atypical lymphocytes in peripheral blood smears made from EDTA-treated and untreated blood. Flow cytometry of the peripheral blood sample and immunohistochemical stains of the subsequent bone marrow biopsy specimen revealed a monoclonal B-cell population positive for CD5, CD20, and cyclin D1 and negative for CD3 and CD23; cytogenetic findings revealed a complex karyotype that included t(11;14). These findings were consistent with mantle cell lymphoma. To our knowledge, the finding of platelet satellitism involving mantle cell lymphoma cells in peripheral blood has not been reported previously.

PMID:
11293905
[PubMed - indexed for MEDLINE]
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