Trends Immunol. 2001 Feb;22(2):92-6.

Structured treatment interruptions to control HIV-1 and limit drug exposure.

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The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Montaner@wistar.upenn.edu

Abstract

Although therapy-mediated suppression of HIV-1 is effective and results in a degree of immune reconstitution, the complications resulting from life-long treatment emphasize the need for alternatives. This review discusses the use of structured interruptions in antiviral therapy to induce drug-free periods of immune-mediated control of HIV-1. Such an approach has the ultimate objective of harnessing anti-viral immune responses, reducing drug exposure (toxicity and cost) and potentially extending the clinical benefits of a suppressive treatment regimen.

PMID:: 11286710; [PubMed - indexed for MEDLINE]

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