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Trends Immunol. 2001 Jan;22(1):52-7.

Divergent and convergent evolution of NK-cell receptors.

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  • 1Immunology Division, Dept of Pathology, University of Cambridge, UK.


Natural killer (NK)-cell receptors specific for major histocompatibility complex (MHC) class I molecules have been identified in humans and mice. Some of the most important receptors are structurally unrelated in the two species: the murine Ly-49 receptors are C-type lectins, while human killer-cell inhibitory receptors (KIRs) belong to the immunoglobulin superfamily. Here, Roland Barten and colleagues describe the divergent and convergent evolution of NK-cell receptors.

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