Format

Send to:

Choose Destination
See comment in PubMed Commons below
Acta Ophthalmol Scand. 2001 Apr;79(2):108-15.

Ocular perfusion and age-related macular degeneration.

Author information

  • 1Indiana University School of Medicine, Indianapolis, Indiana, USA.

Abstract

PURPOSE:

To review the role of ocular perfusion in the pathophysiology of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the industrialized world.

METHODS:

Medline search of the literature published in English or with English abstracts from 1966 to 2000 was performed using various combinations of relevant key words.

RESULTS:

Vascular defects have been identified in both nonexudative and exudative AMD patients using fluorescein angiographic methods, laser Doppler flowmetry, indocyanine green angiography, and color Doppler imaging.

CONCLUSION:

Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simply an association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, or if they are more strongly associated with one particular form of this heterogeneous disease. Further study is warranted.

PMID:
11284745
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk