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    Nat Rev Mol Cell Biol. 2001 Apr;2(4):294-307.

    Cbl: many adaptations to regulate protein tyrosine kinases.

    Source

    Department of Pathology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.

    Abstract

    Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

    PMID:
    11283727
    [PubMed - indexed for MEDLINE]

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