Format

Send to:

Choose Destination
See comment in PubMed Commons below
BMJ. 2001 Mar 31;322(7289):757-63.

Dietary fat intake and prevention of cardiovascular disease: systematic review.

Author information

  • 1Manchester Dental and Education Centre, University Dental Hospital of Manchester, Manchester M15 6FH, UK.

Abstract

OBJECTIVE:

To assess the effect of reduction or modification of dietary fat intake on total and cardiovascular mortality and cardiovascular morbidity.

DESIGN:

Systematic review.

DATA SOURCES:

Cochrane Library, Medline, Embase, CAB abstracts, SIGLE, CVRCT registry, and biographies were searched; trials known to experts were included.

INCLUDED STUDIES:

Randomised controlled trials stating intention to reduce or modify fat or cholesterol intake in healthy adult participants over at least six months. Inclusion decisions, validity, and data extraction were duplicated. Meta-analysis (random effects methodology), meta-regression, and funnel plots were performed.

RESULTS:

27 studies (30 902 person years of observation) were included. Alteration of dietary fat intake had small effects on total mortality (rate ratio 0.98; 95% confidence interval 0.86 to 1.12). Cardiovascular mortality was reduced by 9% (0.91; 0.77 to 1.07) and cardiovascular events by 16% (0.84; 0.72 to 0.99), which was attenuated (0.86; 0.72 to 1.03) in a sensitivity analysis that excluded a trial using oily fish. Trials with at least two years' follow up provided stronger evidence of protection from cardiovascular events (0.76; 0.65 to 0.90).

CONCLUSIONS:

There is a small but potentially important reduction in cardiovascular risk with reduction or modification of dietary fat intake, seen particularly in trials of longer duration.

PMID:
11282859
[PubMed - indexed for MEDLINE]
PMCID:
PMC30550
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk