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Curr Opin Chem Biol. 2001 Apr;5(2):137-43.

Improved biocatalysts by directed evolution and rational protein design.

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  • 1Institute for Chemistry & Biochemistry, Department of Technical Chemistry & Biotechnology, Greifswald University, Germany.


The efficient application of biocatalysts requires the availability of suitable enzymes with high activity and stability under process conditions, desired substrate selectivity and high enantioselectivity. However, wild-type enzymes often need to be optimized to fulfill these requirements. Two rather contradictory tools can be used on a molecular level to create tailor-made biocatalysts: directed evolution and rational protein design.

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