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Curr Med Chem. 2001 Apr;8(5):509-16.

Sequence recognition of DNA by lexitropsins.

Author information

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. goodsell@scripps.edu

Abstract

Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits--pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.

PMID:
11281838
[PubMed - indexed for MEDLINE]
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