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Res Microbiol. 2001 Jan-Feb;152(1):11-6.

Second-order selection in bacterial evolution: selection acting on mutation and recombination rates in the course of adaptation.

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  • 1Inserm E9916, Faculté de médecine Necker Enfants Malades, Université Paris V, France.


The increase in genetic variability of a population can be selected during adaptation, as demonstrated by the selection of mutator alleles. The dynamics of this phenomenon, named second-order selection, can result in an improved adaptability of bacteria through regulation of all facets of mutation and recombination processes.

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