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1: J Dermatol. 2001 Jan;28(1):1-4.Links

Azithromycin monthly pulse vs daily doxycycline in the treatment of acne vulgaris.

Parsad D, Pandhi R, Nagpal R, Negi KS.

Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Acne vulgaris is a common skin disease seen primarily in adolescent and young adults. As the treatment involves long term therapy with antibiotics, an agent with a long half life can be very useful in increasing the compliance. To evaluate the role of a monthly dose of azithromycin and compare it with daily doxycycline, we conducted this randomized comparative study. Sixty patients with moderate to severe acne were randomly assigned to two treatment groups, A & B. Patients in group A received 100 mg doxycycline daily in addition to topical 0.05% tretinoin cream, whereas patients in group B were given 500 mg azithromycin once a day for four days per month along with 0.05% topical tretinoin for a total of 12 weeks. Of the 60 patients, 22 in group A and 28 in group B were evaluated. The monthly dose of azithromycin was found to be as effective as daily doxycycline on a pure protocol basis and statistically significantly better than doxycycline by intention to treat analysis.

PMID: 11280457 [PubMed - indexed for MEDLINE]

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