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JAMA. 2001 Apr 4;285(13):1746-8.

Detection of peanut allergens in breast milk of lactating women.

Author information

  • 1Division of Allergy and Clinical Immunology, St Michael's Hospital, Room 8-161, Victoria Wing, 30 Bond St, Toronto, Ontario, Canada M5B 1W8. pv4588@home.com

Abstract

CONTEXT:

Most individuals who react to peanuts do so on their first known exposure. A potential but unproven route of occult exposure resulting in sensitization to peanut is via breast milk during lactation.

OBJECTIVE:

To investigate the ability of maternal dietary peanut protein to pass into breast milk during lactation.

DESIGN AND SETTING:

Clinical investigation conducted at 2 North American hospitals from March 1999 to October 2000.

PATIENTS:

Twenty-three healthy, lactating women aged 21 to 35 years.

INTERVENTION:

Each woman consumed 50 g of dry roasted peanuts, after which breast milk samples were collected at hourly intervals.

MAIN OUTCOME MEASURES:

Presence in breast milk of total peanut protein, analyzed by a sandwich enzyme-linked immunosorbent assay, and 2 major peanut allergens, Ara h 1 and Ara h 2, detected by immunoblot analysis.

RESULTS:

Peanut protein was detected in 11 of 23 subjects. It was detected in 10 subjects within 2 hours of ingestion and in 1 subject within 6 hours. The median peak peanut protein concentration in breast milk was 200 ng/mL (mean, 222 ng/mL; range, 120-430 ng/mL). Both major peanut allergens Ara h 1 and Ara h 2 were detected.

CONCLUSIONS:

Peanut protein is secreted into breast milk of lactating women following maternal dietary ingestion. Exposure to peanut protein during breastfeeding is a route of occult exposure that may result in sensitization of at-risk infants.

PMID:
11277829
[PubMed - indexed for MEDLINE]
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