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1: J Nat Prod. 2001 Mar;64(3):313-7.Click here to read Links

Three new phenolic compounds from a manipulated plant cell culture, Mirabilis jalapa.

Yang SW, Ubillas R, McAlpine J, Stafford A, Ecker DM, Talbot MK, Rogers B.

Phytera, Inc., 377 Plantation Street, Worcester, MA 01605, USA. syang@phytera.com

Bioassay-guided fractionation of an organic extract of the cell mass from a manipulated plant cell culture of Mirabilis jalapa led to the isolation and subsequent identification of three new phenolic compounds, 1, 2, and 3. The isoflavone 1 and dehydrorotenoid 2 were identified as the principal antifungal principles from this plant cell culture with IC(50)'s of 25 and 48 microg/mL, respectively, against the test organism, Candida albicans DSY1024. The rotenoid 3 was inactive at 200 microg/mL in this assay.

PMID: 11277746 [PubMed - indexed for MEDLINE]