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1: Genome Biol. 2001;2(3):REVIEWS0002. Epub 2001 Mar 9.Click here to read Click here to read Links

Nuclear dynamics: where genes are and how they got there.

Swedlow JR, Lamond AI.

Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. j.swedlow@dundee.ac.uk

DNA is highly organized spatially, both within domains of chromatin along each chromosome and within the nucleus as a whole. Recent studies suggest that chromatin localization can affect transcriptional and replicational activity. The similarity between the movements of chromatin nuclear bodies suggests a common mechanism that regulates nuclear dynamics.

PMID: 11276427 [PubMed - indexed for MEDLINE]

PMCID: PMC138913