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Nat Neurosci. 2001 Apr;4(4):357-8.

Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.

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  • 1CNRS URA 2182, Neurobiologie Mol├ęculaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.


The neuropeptide alpha CGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of alpha CGRP remains unclear. Here we show that mice lacking alpha CGRP display an attenuated response to chemical pain and inflammation. Furthermore, alpha CGRP(-/-) mice do not show changes in heroin self-administration or morphine tolerance, but display a marked decrease in morphine withdrawal signs, suggesting an important contribution of alpha CGRP to opiate withdrawal.

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