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Nat Neurosci. 2001 Apr;4(4):351-2.

Changing specificity of neurotransmitter regulation of rapid dendritic remodeling during synaptogenesis.

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  • 1Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S. Euclid, St. Louis, Missouri 63110, USA.


Wiring the developing nervous system requires appropriate contact between presynaptic axons and postsynaptic dendrites. Rapid movements of filopodia-like structures on immature dendrites are thought to facilitate initial synaptogenic contact with axons. Here we show that not only can different forms of neurotransmission regulate dendritic filopodial motility, but they do so in a developmentally regulated manner, suggestive of a specific relationship between the action of a neurotransmitter and the corresponding type of synapse being formed.

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