Chemotherapy. 2001;47 Suppl 2:30-9.

Antiproliferative effect of somatostatin and analogs.

Bousquet C, Puente E, Buscail L, Vaysse N, Susini C.

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INSERM U 151, CHU Rangueil, IFR 31, Toulouse, France.

Abstract

Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts through five somatostatin receptors (SSTR1-5) which are variably expressed in normal and tumor cells. These receptors regulate a variety of signal transduction pathways including inhibition of adenylate cyclase, regulation of ion channels, regulation of serine/threonine and tyrosine kinases and phosphatases. This review focuses on recent advances in biological mechanisms involved in the antineoplastic activity of somatostatin and analogs.

PMID:: 11275700; [PubMed - indexed for MEDLINE]

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