Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2001 Apr;17(4):206-13.

Nuclear receptors in nematodes: themes and variations.

Author information

  • 1Cambria Biosciences LLC, 2 Preston Court, Bedford, MA 01730, USA. asluder@cambriabio.com

Abstract

Large-scale sequencing efforts are providing new perspectives on similarities and differences among species. Sequences encoding nuclear receptor (NR) transcription factors furnish one striking example of this. The three complete or nearly complete metazoan genome sequences - those of the nematode Caenorhabditis elegans, the fruit fly (Drosophila melanogaster) and the human - reveal dramatically different numbers of predicted NR genes: 270 for the nematode, 21 for the fruit fly and approximately 50 for the human. Although some classes of NRs present in insects and mammals are also represented among the nematode genes, most of the C. elegans NR sequences are distinct from those known in other phyla. Questions regarding the evolution and function of NR genes in nematodes, framed by t00e abundance and diversity of these genes in the C. elegans genome, are the focus of this article.

PMID:
11275326
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk