Neurology. 2001 Mar 27;56(6):781-3.

Preliminary evidence of widespread morphological variations of the brain in dyslexia.

Brown WE, Eliez S, Menon V, Rumsey JM, White CD, Reiss AL.

Source

Stanford Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5719, USA.

Abstract

The MR images of 16 men with dyslexia and 14 control subjects were compared using a voxel-based analysis. Evidence of decreases in gray matter in dyslexic subjects, most notably in the left temporal lobe and bilaterally in the temporoparietooccipital juncture, but also in the frontal lobe, caudate, thalamus, and cerebellum, was found. Widely distributed morphologic differences affecting several brain regions may contribute to the deficits associated with dyslexia.

PMID:: 11274316; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Related citations

Gray matter alteration in dyslexia: converging evidence from volumetric and voxel-by-voxel MRI analyses. [Neuropsychologia. 2005]
Gray matter alteration in dyslexia: converging evidence from volumetric and voxel-by-voxel MRI analyses.
Vinckenbosch E, Robichon F, Eliez S. Neuropsychologia. 2005; 43(3):324-31.
Anatomical correlates of dyslexia: frontal and cerebellar findings. [Brain. 2003]
Anatomical correlates of dyslexia: frontal and cerebellar findings.
Eckert MA, Leonard CM, Richards TL, Aylward EH, Thomson J, Berninger VW. Brain. 2003 Feb; 126(Pt 2):482-94.
Brain classification reveals the right cerebellum as the best biomarker of dyslexia. [BMC Neurosci. 2009]
Brain classification reveals the right cerebellum as the best biomarker of dyslexia.
Pernet CR, Poline JB, Demonet JF, Rousselet GA. BMC Neurosci. 2009 Jun 25; 10:67. Epub 2009 Jun 25.
Review Dyslexia and brain morphology. [Psychol Bull. 1989]
Review Dyslexia and brain morphology.
Hynd GW, Semrud-Clikeman M. Psychol Bull. 1989 Nov; 106(3):447-82.
Review Brain imaging findings in dyslexia. [Pediatr Neonatol. 2010]
Review Brain imaging findings in dyslexia.
Sun YF, Lee JS, Kirby R. Pediatr Neonatol. 2010 Apr; 51(2):89-96.

See reviews... See all...

Cited by 11 PubMed Central articles

Phonetically irregular word pronunciation and cortical thickness in the adult brain. [Neuroimage. 2010]
Phonetically irregular word pronunciation and cortical thickness in the adult brain.
Blackmon K, Barr WB, Kuzniecky R, Dubois J, Carlson C, Quinn BT, Blumberg M, Halgren E, Hagler DJ, Mikhly M, et al. Neuroimage. 2010 Jul 15; 51(4):1453-8. Epub 2010 Mar 17.
White matter microstructural differences linked to left perisylvian language network in children with dyslexia. [Cortex. 2010]
White matter microstructural differences linked to left perisylvian language network in children with dyslexia.
Rimrodt SL, Peterson DJ, Denckla MB, Kaufmann WE, Cutting LE. Cortex. 2010 Jun; 46(6):739-49. Epub 2009 Jul 22.
Review Structural MRI studies of language function in the undamaged brain. [Brain Struct Funct. 2009]
Review Structural MRI studies of language function in the undamaged brain.
Richardson FM, Price CJ. Brain Struct Funct. 2009 Oct; 213(6):511-23. Epub 2009 Jul 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Preliminary evidence of widespread morphological variations of the brain in dysl...
Preliminary evidence of widespread morphological variations of the brain in dyslexia.
Neurology. 2001 Mar 27 ;56(6):781-3.

PubMed
Myocardial gene expression associated with genetic cardiac hypertrophy in the ab...
Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension.
Hypertens Res. 2008 May ;31(5):941-55.

PubMed
Silver diamine fluoride: a caries "silver-fluoride bullet".
Silver diamine fluoride: a caries "silver-fluoride bullet".
J Dent Res. 2009 Feb ;88(2):116-25.

PubMed
Vitamin supplement use and fatal non-Hodgkin's lymphoma among US men and women.
Vitamin supplement use and fatal non-Hodgkin's lymphoma among US men and women.
Am J Epidemiol. 2001 Jun 1 ;153(11):1064-70.

PubMed
Physiology and immunology of the cholinergic antiinflammatory pathway.
Physiology and immunology of the cholinergic antiinflammatory pathway.
J Clin Invest. 2007 Feb ;117(2):289-96.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: