Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
AIDS. 2001 Feb 16;15(3):379-87.

Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa.

Author information

  • 1Department of Paediatrics and Child Health, University of Natal, Congella, South Africa. coutsoud@med.und.ac.za

Abstract

OBJECTIVE:

To determine the risk of HIV transmission by infant feeding modality.

DESIGN AND SETTING:

A prospective study in two hospitals in Durban, South Africa.

PARTICIPANTS:

A total of 551 HIV-infected pregnant women enrolled in a randomized trial of vitamin A.

INTERVENTIONS:

Women self-selected to breastfeed or formula feed after being counselled. Breastfeeders were encouraged to practice exclusive breastfeeding for 3-6 months.

MAIN OUTCOME MEASURES:

Cumulative probabilities of detecting HIV over time were estimated using Kaplan-Meier methods and were compared in three groups: 157 formula-fed (never breastfed); 118 exclusively breastfed for 3 months or more; and 276 mixed breastfed.

RESULTS:

The three feeding groups did not differ in any risk factors for transmission, and the probability of detecting HIV at birth was similar. Cumulative probabilities of HIV detection remained similar among never and exclusive breastfeeders up to 6 months: 0.194 (95% CI 0.136-0.260) and 0.194 (95% CI 0.125-0.274), respectively, whereas the probabilities among mixed breastfeeders soon surpassed both groups reaching 0.261 (95% CI 0.205-0.319) by 6 months. By 15 months, the cumulative probability of HIV infection remained lower among those who exclusively breastfed for 3 months or more than among other breastfeeders (0.247 versus 0.359).

CONCLUSION:

Infants exclusively breastfed for 3 months or more had no excess risk of HIV infection over 6 months than those never breastfed. These findings, if confirmed elsewhere, can influence public health policies on feeding choices available to HIV-infected mothers in developing countries.

Comment in

PMID:
11273218
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk