The primary mediastinal growing teratoma syndrome

A Iyoda; K Hiroshima; T Yusa; T Toyozaki; T Fujisawa; H Ohwada

The primary mediastinal growing teratoma syndrome

Anticancer Res. 2000 Sep-Oct;20(5C):3723-6.

Authors

A Iyoda¹, K Hiroshima, T Yusa, T Toyozaki, T Fujisawa, H Ohwada

Affiliation

¹ Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan. iyoda@haibyo1.m.chiba-u.ac.jp

PMID: 11268445

Abstract

We encountered a case of mediastinal immature teratoma which revealed the feature of the so-called growing teratoma syndrome. A 20-year-old male with a cough was discovered to have an abnormal shadow in the mediastinum. The serum AFP was elevated to 3600 ng/ml. The specimen with percutaneous needle biopsy revealed mature teratoma. The tumor was suspected to be mature teratoma with a malignant component because of the high level of serum AFP and he underwent chemotherapy. The serum AFP declined markedly but the tumor further enlarged. The resected tumor was diagnosed as immature teratoma, although most of the tumor tissue was mature component.

Publication types

Case Reports
Review

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biopsy, Needle
Carboplatin / administration & dosage
Cisplatin / administration & dosage
Cough
Doxorubicin / administration & dosage
Etoposide / administration & dosage
Humans
Magnetic Resonance Imaging
Male
Mediastinal Neoplasms / diagnosis*
Mediastinal Neoplasms / drug therapy
Mediastinal Neoplasms / pathology
Mediastinal Neoplasms / surgery
Radiography, Thoracic
Syndrome
Teratoma / diagnosis*
Teratoma / drug therapy
Teratoma / pathology
Teratoma / surgery
Treatment Outcome
alpha-Fetoproteins / analysis

Substances

alpha-Fetoproteins
Etoposide
Doxorubicin
Carboplatin
Cisplatin