Biochim Biophys Acta. 2001 Mar 19;1518(1-2):145-51.

Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element.

Dailly YP, Zhou Y, Linkhart TA, Baylink DJ, Strong DD.

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Musculoskeletal Disease Center, J.L. Pettis Memorial Veterans' Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.

Abstract

The 1.7 kb human insulin-like growth factor binding protein (IGFBP)-6 gene 5'-flanking region was sequenced and found to have promoter activity in human osteoblasts. The sequence contains four clustered transcription start sites and three retinoic acid response elements (RAREs) with widely spaced half-sites. Only the proximal DR15 RARE was functional. Retinoids increased IGFBP-6 promoter activity up to 3-fold.

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Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element.
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