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Nat Rev Mol Cell Biol. 2001 Mar;2(3):211-6.

Molecular dissection of autophagy: two ubiquitin-like systems.

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  • 1Department of Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki, 444-8585, Japan.


Recent analyses of the genes required for autophagy--intracellular bulk protein degradation--in yeast have revealed two ubiquitin-like systems, both of which are involved in the membrane dynamics of the process. Molecular dissection of these systems is now revealing some surprises.

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