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Biochem Biophys Res Commun. 2001 Mar 23;282(1):249-56.

Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.

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  • 1Institut de Pharmacologie Mol├ęculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Valbonne, Sophia Antipolis, 06560, France.

Abstract

We isolated three novel 2P domain K(+) channel subunits from human. The first two subunits, TALK-1 and TALK-2, are distantly related to TASK-2. Their genes form a tight cluster of 25 kb on chromosome 6p21.1-p21.2. The corresponding channels produce quasi-instantaneous and non-inactivating currents that are activated at alkaline pHs. These currents are sensitive to Ba(2+), quinine, quinidine, chloroform, halothane, and isoflurane but are not affected by TEA, 4-AP, Cs(+), arachidonic acid, hypertonic solutions, agents activating protein kinases C and A, changes of internal Ca(2+) concentrations, and by activation of G(i) and G(q) proteins. TALK-1 is exclusively expressed in the pancreas. TALK-2 is mainly expressed in the pancreas, but is also expressed at a lower level in liver, placenta, heart, and lung. We also cloned a third subunit, named hTHIK-2 which is present in many tissues with high levels again in the pancreas but which could not be functionally expressed.

Copyright 2001 Academic Press.

PMID:
11263999
[PubMed - indexed for MEDLINE]
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