Pac Symp Biocomput. 2001:167-78.

Nucleotide substitutions and the evolution of duplicate genes.

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Computational Science Institute, University of Oregon, Eugene, OR, USA.

Abstract

This paper describes software created to search for and analyze pairs of duplicate genes within a genome. The process is based on a program that uses aligned amino acid sequences to generate a corresponding alignment of the underlying nucleotide sequences and perform a codon by codon comparison of the nucleotides. Observed numbers of nucleotide substitutions can be used to make inferences about the ages of gene duplication events and the effects of natural selection acting on duplicate genes.

PMID:: 11262937; [PubMed - indexed for MEDLINE]

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