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Tidsskr Nor Laegeforen. 2001 Feb 10;121(4):446-9.

[Extrahepatic manifestations in hepatitis C. Are they overlooked?].

[Article in Norwegian]

Author information

  • 1Medisinsk avdeling Nordland Sentralsykehus 8092 Bodø. Gakristi@online.no

Abstract

BACKGROUND:

There are accumulating documentation of autoimmune mediated extrahepatic manifestations of hepatitis C virus infection. The virus is hepatotrophic and lymphotrophic. It mutates frequently with subsequent inadequate immune response and chronic stimulation of T and B cells. This may be one explanation for the increased frequency of the autoimmune diseases associated with hepatitis C virus infection.

MATERIAL AND METHODS:

In this review of the literature published in the period of 1990 to 2000, we present the most common extrahepatic manifestations of the hepatitis C virus infection.

RESULTS:

Mixed cryoglobulinaemia, membranoproliferative glomerulonephritis and membranous glomerulonephritis are highly associated with hepatitis C infection. Other autoimmune diseases may also be associated with hepatitis C infection, but further documentation is necessary.

INTERPRETATION:

Extrahepatic manifestations of hepatitis C virus infection are associated with several autoimmune diseases. When diagnosing an autoimmune disease, a test for a coinfection of hepatitis C is highly recommended. Antiviral therapy with interferon may in some cases reduce the activity of the autoimmune disease.

PMID:
11255860
[PubMed - indexed for MEDLINE]
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