Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Dev Neurosci. 2001 Apr;19(2):175-82.

The acquisition of motoneuron subtype identity and motor circuit formation.

Author information

  • 1Department of Neurosciences, Case Western Reserve University, School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106-4975, USA. ltl@po.cwru.edu

Abstract

Experiments in chick embryos using classical transplantation techniques introduced by Viktor Hamburger are reviewed; these demonstrated that chick-limb innervating motoneurons become specified by extrinsic signals prior to axon outgrowth and that they selectively grow to appropriate muscles by actively responding to guidance cues within the limb. More recent experiments reveal that fast/slow and flexor/extensor subclasses of motoneurons are distinct by E4-5 and that they exhibit patterned spontaneous activity while still growing to their targets. These observations are then related to the combinatorial code of LIM transcription factor expression, which has been hypothesized to specify motoneuron subtypes.

PMID:
11255031
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk