Nat Rev Genet. 2000 Nov;1(2):109-15.

Capitalizing on large-scale mouse mutagenesis screens.

Source

Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA. mjustice@bcm.tmc.edu

Abstract

Variation is the crux of genetics. Mutagenesis screens in organisms from bacteria to fish have provided a battery of mutants that define protein functions within complex pathways. Large-scale mutation isolation has been carried out in Caenorhabditis elegans, Drosophila melanogaster and zebrafish, and has been recently reported in the mouse in two screens that have generated many new, clinically relevant mutations to reveal the power of phenotype-driven screens in a mammal.

PMID:: 11253650; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review From Zebrafish to human: modular medical models. [Annu Rev Genomics Hum Genet. 2...]
Review From Zebrafish to human: modular medical models.
Shin JT, Fishman MC. Annu Rev Genomics Hum Genet. 2002; 3:311-40. Epub 2002 Apr 15.
Review Genetic models in pathogenesis. [Annu Rev Genet. 2004]
Review Genetic models in pathogenesis.
Pradel E, Ewbank JJ. Annu Rev Genet. 2004; 38:347-63.
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. [Curr Biol. 1994]
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate.
Mullins MC, Hammerschmidt M, Haffter P, Nüsslein-Volhard C. Curr Biol. 1994 Mar 1; 4(3):189-202.
Review Zebrafish genetics and its implications for understanding vertebrate development. [Hum Mol Genet. 1997]
Review Zebrafish genetics and its implications for understanding vertebrate development.
Ingham PW. Hum Mol Genet. 1997; 6(10):1755-60.
Review Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. [Expert Opin Ther Targets. 2002]
Review Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins.
Reiter LT, Bier E. Expert Opin Ther Targets. 2002 Jun; 6(3):387-99.

See reviews... See all...

Cited by 12 PubMed Central articles

Review Technical approaches for mouse models of human disease. [Dis Model Mech. 2011]
Review Technical approaches for mouse models of human disease.
Justice MJ, Siracusa LD, Stewart AF. Dis Model Mech. 2011 May; 4(3):305-10.
Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele. [Eur J Neurosci. 2010]
Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele.
Swanson DJ, Steshina EY, Wakenight P, Aldinger KA, Goldowitz D, Millen KJ, Chizhikov VV. Eur J Neurosci. 2010 Sep; 32(5):707-16. Epub 2010 Aug 16.
Review Metabolic syndrome components in murine models. [Endocr Metab Immune Disord Dru...]
Review Metabolic syndrome components in murine models.
Lawson HA, Cheverud JM. Endocr Metab Immune Disord Drug Targets. 2010 Mar; 10(1):25-40.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Capitalizing on large-scale mouse mutagenesis screens.
Capitalizing on large-scale mouse mutagenesis screens.
Nat Rev Genet. 2000 Nov ;1(2):109-15.

PubMed
[Williams syndrome: new insights into genetic etiology, pathogenesis and clinica...
[Williams syndrome: new insights into genetic etiology, pathogenesis and clinical aspects].
Ned Tijdschr Geneeskd. 2001 Mar 3 ;145(9):396-400.

PubMed
Modulation of neuroimmune parameters during the eustress of humor-associated mir...
Modulation of neuroimmune parameters during the eustress of humor-associated mirthful laughter.
Altern Ther Health Med. 2001 Mar ;7(2):62-72, 74-6.

PubMed
Nuclear compartmentalization and gene activity.
Nuclear compartmentalization and gene activity.
Nat Rev Mol Cell Biol. 2000 Nov ;1(2):137-43.

PubMed
Methodological considerations for researchers and practitioners using pedometers...
Methodological considerations for researchers and practitioners using pedometers to measure physical (ambulatory) activity.
Res Q Exerc Sport. 2001 Mar ;72(1):1-12.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: