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Nat Rev Mol Cell Biol. 2001 Feb;2(2):98-106.

SNARE-mediated membrane fusion.

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  • 1Renovis Inc., 747 Fifty Second Street, Oakland, California 94609, USA.


SNARE proteins have been proposed to mediate all intracellular membrane fusion events. There are over 30 SNARE family members in mammalian cells and each is found in a distinct subcellular compartment. It is likely that SNAREs encode aspects of membrane transport specificity but the mechanism by which this specificity is achieved remains controversial. Functional studies have provided exciting insights into how SNARE proteins interact with each other to generate the driving force needed to fuse lipid bilayers.

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